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According to eMedicine: “Treatment for REM behavior disorder is initiated with clonazepam at 0.5-1.5 mg taken at bedtime. This medication has been shown to be beneficial in the long-term. Drug discontinuation often results in prompt relapse. The exact mechanism of action of clonazepam in patients with REM behavior disorder is not known, but its serotonergic properties may inhibit nocturnal motor activity in the brainstem and thus prevent arousals. Tricyclic antidepressants occasionally are used in the treatment of REM behavior disorder. Imipramine, which has serotonergic effects, has been used in the treatment of REM behavior disorder, but the effects are unpredictable. Anecdotal reports of levodopa/carbidopa, gabapentin, and clonidine have been published, but the benefit of these drugs has not been systemically evaluated.” Source: http://www.clinicalanswers.nhs.uk/index.cfm?question=5226